The Thermodynamic Solvers (P-THERMAL) enable the modeling of heat transfer in living tissue using advanced perfusion and thermoregulation models. The two solvers adapted from SEMCAD X are based on 1) the finite-difference time-domain solver with conformal surface correction and 2) a steady-state finite volume solver to support adaptive rectilinear meshes and arbitrary active domain shapes.
Treatment planning for liver radiofrequency ablation (RFA) (specific absorption rate (SAR), CEM43 thermal tissue damage assessment).
The solvers allow for the coupled simulation of local vascular effects using discrete networks (1D trees) and, in the near future, CFD results.
Exclusive thermal damage and effect quantification models, e.g., T-CEM43, are included.
The P-THERMAL solvers have been extensively validated by comparison with analytically solvable cases, experimental measurements under controlled conditions, and in vivo measurements. Comprehensive documentation is available for Sim4Life.
In vivo temperature evaluation of radiofrequency (RF)-safe pacemakers.
Optimization of liver tumor focused ultrasound (FUS) ablation considering
Optimized positioning and steering of hyperthermia